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Particle Contamination in High-Purity Process Chemicals
Vaporized Hydrogen Peroxide (VHP) Resistance Testing for MiniCapt Pro Microbial Sampler

Vaporized Hydrogen Peroxide (VHP) serves as a potent oxidizer and has long been acknowledged for its effectiveness in sterilization within enclosed filling isolators. With the rising prevalence of isolator applications, there’s an increasing demand for robust samplers capable of enduring such environments. The MiniCapt® Pro Remote Microbial Sampler features an internal flow path designed to resist the corrosive impacts of VHP.

Microbial Data Collection environmental monitoring biocapt single use 10 years air sampler for microbiological monitoring
Optimal Microbial Sampling of Air Criteria

Microbial sampling of air in pharmaceutical manufacturing facilities is performed using several methods: surface sampling, passive aerosol (air) environmental sampling, and active aerosol (air) environmental sampling. Each of these methods produces a result based on the growth of microbial colonies on the surface of a collection media (typically agar), but the specific instruments and techniques vary between the methods. For all the sampling methods, it is important to be sure that the sample accurately reflects the environmental microbiological condition. This is often measured and discussed in terms of collection efficiency. The focus of this paper will mainly be on active air sampling, but there are sampling characteristics for each type of sampling that ensure the optimized collection efficiency.

Nanoparticle Counter NanoAir 10 for semiconductor tool contamination monitoring
Airborne Nanoparticle Counter to Detect Contamination in Semiconductor Tools

The increasing attention on driving better product yield performance with advanced technology nodes has drawn reasonable discussion for in-tool monitoring to reduce nanoparticles that can have an impact on yield. With that in mind, Particle Measuring Systems (PMS) launched the new NanoAir™ 10 Condensation Particle Counter that measures particles down to 10 nm and the ParticleSeeker™ Smart Manifold system which is the first-ever manifold designed to handle nanoparticle transport. This product will unlock a new world of monitoring possibilities, providing a look into a current blind spot of the requirements and needs in the industry.

Why is 50% the Limit for Particle Counting Efficiency Sizing Thresholds?

Particle counting efficiency is crucial in particle measurement, especially when using optical particle counters. This term denotes the likelihood of precisely detecting and enumerating particles within a specified size spectrum. In this context, the term “counting efficiency” represents the ability of the particle counter to quantify particles of a given size accurately. It measures the instrument’s performance, indicating how effectively it can detect and count particles of various sizes.

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