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Archives: Application Notes

contamination control strategy for a fill line
Microbial Monitoring of Compressed Gas

Compressed gases, such as nitrogen, carbon dioxide, and oxygen, are used for a variety of applications in pharmaceutical manufacturing. These applications, such as aseptic packaging, purging, and filtration, are critical processes monitored for their efficacy. To avoid sampling compressed gases, it has been speculated by some manufacturers that the rapid decompression of a gas when exiting its container kills any microbial contamination. However, it has been shown by multiple studies that microbial survival is not impacted by the typical compression or decompression seen in pharmaceutical process gases.
HandiLaz Mini II handheld particle counter
The Benefits of Particle Counting with the HandiLaz® Mini II Handheld Particle Counter

Modern manufacturing frequently requires clean environments that are designed, constructed, and sustained to enable the highest yields possible while also hitting predictable throughput targets. This commonly involves achieving a specified cleanroom classification to establish the level of cleanroom performance, and subsequent sustaining efforts that are efficient and nimble. Having the right particle detection equipment for this application is necessary to accomplish these tasks.
Process Chemical Particle
High-Purity Process Chemical
Particle Contamination Control

High-Purity Process Chemical Particle Contamination Control has become increasingly complex due to nanometer technology. As semiconductor devices become increasingly complex, and the critical particle size for today’s leading-edge technology nodes decreases into the sub-10 nm size-range, the control and mitigation of potentially yield-impacting particle contamination at the smallest possible particle size becomes ever more crucial. Until recently, there has been a significant sensitivity gap between the critical particle size and the detection limit of traditional chemical particle counters. This paper covers solutions…