In the previous post of the Troubleshooting for Liquid Particle Counting series, the importance of having a constant set flow rate was demonstrated. This segment concerns the effects of background scatter.
In the previous post of the Troubleshooting for Liquid Particle Counting series, the importance of normal particle size distribution was discussed. This segment concerns the effects of flow rate deviations.
In the previous post of the Troubleshooting for Liquid Particle Counting series, specifications that provide operators quality data control were outlined. This segment concerns the importance of normal particle size distributions and the effects of flow rate deviations.
Operators can take several easy steps to ensure that quality data is collected from an optical particle counter (OPC). In this blog series, common misunderstandings and performance issues about OPCs are discussed to help the operator reach proper conclusions when questions arise about the validity of the data.
Our last blog on this topic discussed improved biological efficiency by design. Today we will discuss the statistical corrections for viable particle reading accuracy. The values in each table are calculated from Feller’s formula (Feller, 1950): Pr = N [1/N + 1/N – 1 + 1/N – 2 + 1/N – r + 1]. The […]
Our last blog on this topic discussed the technological advances that have changed sterility assurance. Today we address rapid microbiology methods and the impact on sterility assurance. Environmental Monitoring (EM), particularly in Pharmaceutical manufacturing facilities, where the risk of microbial contamination is controlled through aseptic processing, comprises both physical and microbiological test methods. Nonviable particulate […]
Following the last blog, which discussed the regulations and guidelines surrounding advances in sterility assurance, we move on to discuss the technological progress that has made advances in sterility assurance possible.
Over the last decade significant technological advances have been made regarding the sterility and quality of new drug and microbiological products. New treatment and advancements in medical devices have led to an increase in quality of life and life expectancy for millions of patients.
Following the last blog discussing the principles of Feller’s table of statistics, we move on to discuss improved biological count by impactor slit design. By using impactor slits it is easier to determine false positives. For example, the BioCapt Microbial Impactor is used for microbial air sampling in cleanrooms and associated controlled environments. The slits on the […]
Microbiologists rely on the Feller table to correct for undercounting of biological activity. The “Table of statistical corrections according to Feller” is based on the principle that as the number of viable particles — colony forming units (CFUs) — impact on an agar plate increases, the probability that viable particles will enter unoccupied space decreases. […]