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The choice of sampling method is application dependent, according to ISO 14698-1, and must take into consideration a number of factors. For example, appropriate flow rate and impact velocity, collection accuracy and efficiency, and the effect of the sampling method on the surrounding environment are just a few of the factors that must be considered.
For aseptic process monitoring, especially in critical areas, Particle Measuring Systems strongly recommends a fixed (dedicated) microbial sampling system. For monitoring of less critical areas or for spot-checking of microbial contamination, impactor air samplers and slit-to-agar samplers are recommended over settling plates and other methods.